mRNA expression of DOK1-6 in human breast cancer

doi:10.5306/wjco.v5.i2.156

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May 10, 2014 (publication date) through Apr 26, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. May 10, 2014; 5(2): 156-163
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.156

mRNA expression of DOK1-6 in human breast cancer

Tamara Ghanem, James Bracken, Abdul Kasem, Wen G Jiang, Kefah Mokbel

Tamara Ghanem, James Bracken, Abdul Kasem, Kefah Mokbel, London Breast Institute, Princess Grace Hospital, London, W1U 5NY, United Kingdom

Wen G Jiang, Metastasis and Angiogenesis Research Group, University Department of Surgery, Cardiff University, Cardiff, CF14 4XN, United Kingdom

Author contributions: All the authors contributed to this paper equally.

Correspondence to: Kefah Mokbel, Professor, London Breast Institute, Princess Grace Hospital, 42-52 Nottingham Pl, London, W1U 5NY, United Kingdom. kefahmokbel@hotmail.com

Telephone: +44-20-74861234 Fax: +44-20-79082492

Received: November 9, 2013
Revised: January 8, 2014
Accepted: January 17, 2014
Published online: May 10, 2014

Core Tip

Core tip: Several members of the downstream of tyrosine kinase (DOK) protein family are identified as modulators of cell proliferation/growth pathways. In addition deregulation of specific DOK members has been associated with specific cancers. This study identifies DOK-2 and DOK-6 as potential tumor suppressors in breast cancer.