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World J Clin Oncol. May 10, 2014; 5(2): 142-148
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.142
Published online May 10, 2014. doi: 10.5306/wjco.v5.i2.142
Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma
Erik W Larson, Halloran E Peterson, Wayne T Lamoreaux, Alexander R MacKay, Robert K Fairbanks, Jason A Call, Jonathan D Carlson, John J Demakas, Barton S Cooke, Christopher M Lee, Gamma Knife of Spokane, Spokane, WA 99204, United States
Erik W Larson, Halloran E Peterson, Wayne T Lamoreaux, Robert K Fairbanks, Jason A Call, Christopher M Lee, Cancer Care Northwest, Spokane, WA 99204, United States
Erik W Larson, Halloran E Peterson, University of Washington School of Medicine, Seattle, WA 98195, United States
Alexander R MacKay, MacKay and Meyer MDs, Spokane, WA 99202, United States
Benjamin C Ling, Jonathan D Carlson, Inland Neurosurgery and Spine Associates, Spokane, WA 99204, United States
John J Demakas, Spokane Brain and Spine, Spokane, WA 99204, United States
Author contributions: Larson EW created conducted the literature review, generated the figures, and wrote the manuscript; Peterson HE and Lee CM contributed to the literature review, figure generation, and manuscript writing; Lamoreaux WT, MacKay AR, Fairbanks RK, Call JA, Carlson JD, Ling BC, Demakas JJ and Cooke BS contributed to the writing of the manuscript.
Correspondence to: Christopher M Lee, MD, Gamma Knife of Spokane, 910 W 5th Ave, Suite 102, Spokane, WA 99204, United States. lee@ccnw.net
Telephone: +1-509-2281000 Fax: +1-509-2281183
Received: December 18, 2013
Revised: March 27, 2014
Accepted: April 16, 2014
Published online: May 10, 2014
Revised: March 27, 2014
Accepted: April 16, 2014
Published online: May 10, 2014
Core Tip
Core tip: Glioblastoma is the most common malignant primary neoplasm of the brain. Despite aggressive, upfront therapy, most patients will experience a recurrence of their tumor six months after treatment. This review article analyzes the outcomes of clinical trials that utilized Gamma Knife radiosurgery as salvage therapy for recurrent glioblastoma. Other modalities of radiosurgery were excluded from this study as there is variability in the targeting precision and radiation dosage fall off. Gamma Knife can be used to target tumors that are adjacent to eloquent brain tissue, thus allowing it to treat a wider population of patients, improving overall survival.