Monitoring adenoviral based gene delivery in rat glioma by molecular imaging

doi:10.5306/wjco.v4.i4.91

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Nov 10, 2013 (publication date) through Apr 27, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Nov 10, 2013; 4(4): 91-101
Published online Nov 10, 2013. doi: 10.5306/wjco.v4.i4.91

Monitoring adenoviral based gene delivery in rat glioma by molecular imaging

Nadimpalli Ravi S Varma, Kenneth N Barton, Branislava Janic, Adarsh Shankar, ASM Iskander, Meser M Ali, Ali S Arbab

Nadimpalli Ravi S Varma, Branislava Janic, Adarsh Shankar, ASM Iskander, Meser M Ali, Ali S Arbab, Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, Detroit, MI 48202, United States

Kenneth N Barton, Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202, United States

Author contributions: Varma NRS and Arbab AS carried out the experimental design, data analysis; Varma NRS carried out the experiments (tumour model development, infections, cell labelling, SPECT imaging) and manuscript writing; Varma NRS, Ali MM and Arbab AS performed the MRI imaging and analysis; Varma NRS, Iskander ASM and Shankar A carried out histological staining and analysis; Barton KN carried out design of viral vectors; Varma NRS and Janic B carried out viral production; Arbab AS carried out the SPECT and MRI image analysis; all authors read and approved the final manuscript.

Supported by NIH Grants 1R21CA129801 (to Arbab AS); R01CA122031 (to Arbab AS)

Correspondence to: Nadimpalli Ravi S Varma, PhD, Cellular and Molecular Imaging Laboratory, Department of Radiology, Henry Ford Hospital, 1 Ford place, 2F, Box 82, Detroit, MI 48202, United States. ravin@rad.hfh.edu

Telephone: +1-313-8744349 Fax: +1-313-8744494

Received: February 22, 2013
Revised: May 21, 2013
Accepted: July 9, 2013
Published online: November 10, 2013

Core Tip

Core tip: Endothelial progenitor cells (EPCs) can be transfected with replication competent adenoviral vector carrying therapeutic/reporter gene and the transfected EPCs can be used to deliver the gene in tumor gene therapy. EPCs can be used as both imaging and therapeutic probes.