Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Clin Oncol. Oct 24, 2026; 17(10): 124078
Published online Oct 24, 2026. doi: 10.5306/wjco.124078
Published online Oct 24, 2026. doi: 10.5306/wjco.124078
Impact of different surgical approaches on prognosis in patients with pancreatic neck cancer: A retrospective cohort study
Ming-Jian Ma, He Cheng, Yu-Sheng Chen, Xian-Jun Yu, Chen Liu, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Ming-Jian Ma, Yu-Sheng Chen, Chen Liu, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai Pancreatic Cancer Institute, Shanghai 200000, China
Co-first authors: Ming-Jian Ma and He Cheng.
Author contributions: Ma MJ contributed to data curation, investigation, writing original draft; Cheng H contributed to methodology, resources, supervision; Chen YS contributed to formal analysis, software, validation; Liu C and Yu XJ contributed to conceptualization, funding acquisition, editing.
AI contribution statement: No artificial intelligence tools were used in the preparation of this manuscript.
Supported by The National Key Research and Development Program, “Deep Sea and Polar Region Key Technologies and Equipment”, No. 2022YFC2804800; National Natural Science Foundation of China, No. 82072693, No. 82472954, No. 82503291, and No. 82573937; and Natural Science Foundation of Shanghai, No. 25ZR1402089.
Institutional review board statement: This study protocol was approved by Ethics Committee of Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University.
Informed consent statement: Written informed consent was waived by the Ethics Committee of Fudan University Shanghai Cancer Center because this study was retrospective in nature and all patient data were de-identified and analyzed anonymously.
Conflict-of-interest statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.
Corresponding author: Chen Liu, MD, PhD, Chief Physician, Department of Pancreatic Sur
Received: June 5, 2026
Revised: August 5, 2026
Accepted: October 9, 2026
Published online: October 24, 2026
Processing time: 139 Days and 10.4 Hours
Revised: August 5, 2026
Accepted: October 9, 2026
Published online: October 24, 2026
Processing time: 139 Days and 10.4 Hours
Core Tip
Core Tip: This retrospective cohort study of 174 patients with pancreatic neck cancer without gastroduodenal artery invasion compared distal pancreatectomy (DP), pancreaticoduodenectomy (PD), and total pancreatectomy (TP). After multivariable adjustment, surgical procedure was not an independent predictor of overall or disease-free survival; T stage, tumor differentiation, and R1 resection were. When R0 clearance can be achieved by DP, extending resection to PD or TP does not appear to improve survival.