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World J Clin Oncol. Aug 24, 2025; 16(8): 108557
Published online Aug 24, 2025. doi: 10.5306/wjco.v16.i8.108557
Mucinous cystic neoplasms of the liver: Literature review and case series
Ottavia Cicerone, Giorgia Basilico, Claudio Tassi, Caterina Antoniacomi, Federica Lucev, Salvatore Corallo, Alessandro Vanoli, Marcello Maestri
Ottavia Cicerone, Giorgia Basilico, Claudio Tassi, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia 27100, Italy
Caterina Antoniacomi, Department of Molecular Medicine, University of Pavia, Pavia 27100, Italy
Federica Lucev, Department of Diagnostic Imaging, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy
Salvatore Corallo, Department of Oncology, Department of Internal Medicine and Medical Therapy, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia 27100, Italy
Alessandro Vanoli, Department of Molecular Medicine - Pathological Anatomy, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy
Marcello Maestri, General Surgery Unit I - Liver Service, Fondazione IRCCS Policlinico San Matteo, Pavia 27100, Italy
Author contributions: Cicerone O contributed to the concept and design of the study, data analysis and writing of the original draft; Basilico G contributed to the writing of the original draft and data curation; Tassi C contributed to data curation and reference screening; Antoniacomi C contributed to figure preparation and reference screening; Lucev F contributed to the review and editing of the manuscript and figure preparation. Corallo S contributed to the review and editing of the manuscript; Vanoli A contributed to the review and editing of the manuscript, reference screening and figure preparation; Maestri M contributed to the concept and design of the study, manuscript review and editing, supervision and project administration.
Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marcello Maestri, MD, PhD, Professor, General Surgery Unit I - Liver Service, Fondazione IRCCS Policlinico San Matteo, P.le Golgi 19, Pavia 27100, Italy. m.maestri@smatteo.pv.it
Received: April 17, 2025
Revised: May 18, 2025
Accepted: July 24, 2025
Published online: August 24, 2025
Processing time: 125 Days and 16.3 Hours
Core Tip

Core Tip: Mucinous cystic neoplasms of the liver are rare cystic tumors with malignant potential, predominantly affecting middle-aged women. The 2010 World Health Organization classification distinguishes them from other hepatic cysts based on the presence of ovarian-like stroma. The differential diagnosis is challenging, as imaging features often overlap with other cystic liver lesions. Given the risk of recurrence and malignant transformation, complete surgical resection remains the treatment of choice. Histopathological confirmation is essential for definitive diagnosis.