Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2025; 16(6): 106798
Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.106798
Transarterial chemoembolization plus lenvatinib with or without protein-1 inhibitor for hepatocellular carcinoma with portal vein tumor thrombus
Shuai Liu, Yao-Hui Liu, Hong-Bo Ni, Jia-Jian Li, Ze-Tao Wu, Luo-Luo Wang, Yi Ruan, Xin-Hua Zhou
Shuai Liu, Yao-Hui Liu, Hong-Bo Ni, Jia-Jian Li, Ze-Tao Wu, Luo-Luo Wang, Yi Ruan, Xin-Hua Zhou, Department of Hepatobiliary and Pancreatic Surgery, Li Huili Hospital Affiliated to Ningbo University, Ningbo 315000, Zhejiang Province, China
Co-corresponding authors: Xin-Hua Zhou and Yi Ruan.
Author contributions: Liu S, Liu YH, Ruan Y and Zhou XH designed the research study; Liu YH, Ni HB, Li JJ and Wu ZT performed the research; Liu S and Li JJ analyzed the data and wrote the manuscript; Liu S and Wang LL analyzed the data; Ruan Y and Zhou XH acquired funding and provided supervision; all authors have read and approved the final manuscript.
Supported by Zhejiang Province Medicine and Health Science and Technology Project, No. 2023KY239; and Zhejiang Province Traditional Chinese Medicine Science and Technology Plan Project, No. 2024ZL949.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Li Huili Hospital Affiliated to Ningbo University (No. KY2024SL463-01).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: Technical appendix, statistical code, and dataset are available from the corresponding author at zhouxinhua1002@163.com. Participants gave informed consent for data sharing consent was not obtained but the presented data are anonymized and the risk of identification is low.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Hua Zhou, Chief Physician, Professor, Department of Hepatobiliary and Pancreatic Surgery, Li Huili Hospital Affiliated to Ningbo University, No. 1111 Jiangnan Road, Yinzhou District, Ningbo 315000, Zhejiang Province, China. zhouxinhua1002@163.com
Received: March 9, 2025
Revised: April 7, 2025
Accepted: April 29, 2025
Published online: June 24, 2025
Processing time: 104 Days and 18 Hours
Core Tip

Core Tip: This study evaluates the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib plus death protein-1 inhibitors (TACE-L-P) vs TACE combined with lenvatinib (TACE-L) in treating hepatocellular carcinoma with portal vein tumor thrombus (HCC-PVTT). The TACE-L-P regimen showed significantly improved overall survival, progression-free survival, and response rates compared to TACE-L. The safety profiles were comparable, with no severe treatment-related adverse events. These findings suggest that TACE-L-P may be a promising therapeutic option for HCC-PVTT patients.