Yu PY, Liu F, Jiao Y, Zhao YC, Liu YH. Depression in gastric cancer patients: Integrated therapeutic strategies and clinical implications. World J Clin Oncol 2025; 16(6): 106229 [DOI: 10.5306/wjco.v16.i6.106229]
Corresponding Author of This Article
Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Jun 24, 2025; 16(6): 106229 Published online Jun 24, 2025. doi: 10.5306/wjco.v16.i6.106229
Depression in gastric cancer patients: Integrated therapeutic strategies and clinical implications
Pei-Yuan Yu, Feng Liu, Yan Jiao, Yue-Chen Zhao, Ya-Hui Liu
Pei-Yuan Yu, Yan Jiao, Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Feng Liu, Department of Oncology, Tonghua Central Hospital, Tonghua 134001, Jilin Province, China
Yue-Chen Zhao, Department of Radiation Oncology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Yu PY contributed to revisions to the final manuscript; Liu F wrote the initial draft; Jiao Y contributed to literature review; Jiao Y, Zhao YC, and Liu YH contributed to the study design. All authors approved the final version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Received: February 20, 2025 Revised: April 22, 2025 Accepted: May 18, 2025 Published online: June 24, 2025 Processing time: 120 Days and 19.2 Hours
Core Tip
Core Tip: Depression is a common and impactful comorbidity in gastric cancer patients, significantly affecting treatment adherence, quality of life, and survival. A bidirectional relationship exists between depression and gastric cancer, where psychological distress exacerbates cancer progression, and cancer-related burdens worsen depressive symptoms. Effective management requires a holistic, integrated approach, combining pharmacological treatments, psychotherapeutic interventions, and complementary therapies. Multidisciplinary care, incorporating emotional support, pain management, and nutritional strategies, is crucial for improving both psychological and physical outcomes. Future research should focus on personalized therapies targeting both stress-related pathways and individualized psychosocial support to optimize patient well-being and treatment efficacy.
