Basic Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2023; 14(8): 297-310
Published online Aug 24, 2023. doi: 10.5306/wjco.v14.i8.297
Immune responses of six-transmembrane epithelial antigen of the prostate 4 functions as a novel biomarker in gastric cancer
Ze-Xuan Fang, Yan-Yu Hou, Zheng Wu, Bing-Xuan Wu, Yu Deng, Hua-Tao Wu, Jing Liu
Ze-Xuan Fang, Yan-Yu Hou, Zheng Wu, Jing Liu, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Bing-Xuan Wu, Yu Deng, Hua-Tao Wu, Department of General Surgery, First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China
Author contributions: Liu J and Fang ZX designed the research study; Fang ZX performed the research; Fang ZX, Hou YY, Wu Z, Wu BX, Deng Y, and Wu HT analyzed the research and wrote the manuscript; Liu J revised the manuscript critically; and all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82273457 and No. 81501539; Guangdong Basic and Applied Basic Research Foundation, No. 2023A1515012762 and No. 2021A1515012180; Special Grant for Key Area Programs of Guangdong Department of Education, No. 2021ZDZX2040; and Science and Technology Special Project of Guangdong Province, No. 210715216902829.
Institutional review board statement: The current study was reviewed and approved by the Ethics Committee of Shantou University Medical College (Approval No. SUMC-2022-075).
Informed consent statement: The informed consent was waived by the Ethics Committee because our experiment was conducted on commercial microarray.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liu, MD, PhD, Academic Research, Associate Professor, Research Scientist, Senior Scientist, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, China. jliu12@stu.edu.cn
Received: May 10, 2023
Peer-review started: May 10, 2023
First decision: June 7, 2023
Revised: June 19, 2023
Accepted: July 19, 2023
Article in press: July 19, 2023
Published online: August 24, 2023
Core Tip

Core Tip: The present study analyzed the expression level of six-transmembrane epithelial antigen of the prostate 4 (STEAP4) in gastric cancer (GC) and found that high STEAP4 expression is significantly associated with poor survival of patients. STEAP4 is positively correlated with immune infiltration of different types of immune cells, and has strong correlations with most immune markers. STEAP4 may become a potential biomarker for predicting the prognosis of GC patients.