Basic Study
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World J Clin Oncol. May 24, 2023; 14(5): 203-214
Published online May 24, 2023. doi: 10.5306/wjco.v14.i5.203
Thymoquinone enhances the antioxidant and anticancer activity of Lebanese propolis
Sima AlDreini, Zaynab Fatfat, Najwa Abou Ibrahim, Maamoun Fatfat, Hala Gali-Muhtasib, Hala Khalife
Sima AlDreini, Najwa Abou Ibrahim, Hala Khalife, Rammal Rammal Laboratory (ATAC Group), Faculty of Sciences I, Hadath 1003, Lebanon
Zaynab Fatfat, Maamoun Fatfat, Hala Gali-Muhtasib, Department of Biology, American University of Beirut, Beirut 1107-2020, Lebanon
Hala Khalife, Applied Biochemistry Laboratory, School of Pharmacy, Camerino University, Camerino 62032, Italy
Author contributions: AlDreini S carried out lab work as part of her MSc thesis, performed analysis and interpretation of data; Fatfat Z drafted the manuscript; Abou Ibrahim N provided propolis, and contributed intellectually to the study; Fatfat M supervised the experimental work; Khalife H reviewed the manuscript and contributed in the critical appraisal of data; Gali-Muhtasib H conceived the project, supervised the work, and edited the manuscript draft; All authors have read and approved the final manuscript.
Supported by the Lebanese University and the Undergraduate Research Experience funds at the American University of Beirut.
Institutional review board statement: There was no need to provide an Institutional Review Board Approval Form or Document since no human or animal subjects were involved in this study.
Conflict-of-interest statement: All the authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Hala Khalife, PhD, Professor, Rammal Rammal Laboratory (ATAC Group), Faculty of Sciences I, Rafic Hariri University Campus, Hadath 1003, Lebanon and Applied Biochemistry Laboratory, School of Pharmacy, Camerino University, Camerino 62032, Italy.
Received: December 28, 2022
Peer-review started: December 28, 2022
First decision: March 15, 2023
Revised: March 24, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 24, 2023
Core Tip

Core Tip: Combining Thymoquinone with Lebanese propolis enhanced its antioxidant activity and its anticancer effects against breast and colorectal cancer cells. The combination of these natural products could have potential health benefits and could possibly prevent oxidative stress mediated diseases including cancer.