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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jun 24, 2022; 13(6): 540-552
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.540
Published online Jun 24, 2022. doi: 10.5306/wjco.v13.i6.540
Epstein-Barr virus-associated smooth muscle tumors in immunocompromised patients: Six case reports
Afshin A Khan, Anirudh Yalamanchali, Djibril Niang, Department of Internal Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Bassam N Estfan, Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Erica C Savage, Department of Pathology, Cleveland Clinic, Cleveland, OH 44195, United States
Clifton G Fulmer, Hailey L Gosnell, Department of Pathology, Cleveland Clinic Foundation, Cleveland, OH 44195, United States
Jamak Modaresi Esfeh, Department of Gastroenterology, Hepatology and Nutrition , Cleveland Clinic, Cleveland, OH 44195, United States
Author contributions: Khan AA wrote the manuscript; Bassam BN and Esfeh JM conceptualized and proofread the paper; Yalamanchali A and Niang D contributed to the paper; Savage E, Fulmer CG, and Gosnell HL provided input on pathology including preparing slides; and All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from all six patients or healthcare power of attorney, where applicable, for the publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016). The manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Afshin A Khan, MD, Doctor, Department of Internal Medicine, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195, United States. khana13@ccf.org
Received: January 12, 2022
Peer-review started: January 12, 2022
First decision: March 24, 2022
Revised: April 6, 2022
Accepted: May 12, 2022
Article in press: May 12, 2022
Published online: June 24, 2022
Peer-review started: January 12, 2022
First decision: March 24, 2022
Revised: April 6, 2022
Accepted: May 12, 2022
Article in press: May 12, 2022
Published online: June 24, 2022
Core Tip
Core Tip: Epstein-Barr virus associated smooth muscle tumor (EBV-SMT) is a rare oncological entity. Only a handful of case series have shed light on the presence of EBV-SMT in individuals, most of whom are immunocompromised. EBV-SMT should not be confused with post-transplant lymphoproliferative disorder. Histopathology should help guide the diagnosis.