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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. May 24, 2022; 13(5): 314-322
Published online May 24, 2022. doi: 10.5306/wjco.v13.i5.314
Published online May 24, 2022. doi: 10.5306/wjco.v13.i5.314
Neoadjuvant treatment in non-small cell lung cancer: New perspectives with the incorporation of immunotherapy
Carlos Aguado, Mónica Antoñanzas, Department of Medical Oncology, Hospital Clínico Universitario San Carlos, Madrid 28040, Spain
Luis Chara, Department of Medical Oncology, Hospital Universitario de Guadalajara, Guadalajara 19002, Spain
Jose Maria Matilla Gonzalez, Department of Thoracic Surgery, Hospital Clínico Universitario de Valladolid, Valladolid 47005, Spain
Unai Jiménez, Department of Thoracic Surgery, Hospital Universitario Cruces, Barakaldo, Bizkaia 48903, Basque Country, Spain
Raul Hernanz, Department of Radiation Oncology, Hospital Universitario Ramón y Cajal, Madrid 28034, Spain
Xabier Mielgo-Rubio, Department of Medical Oncology, Hospital Universitario Fundación Alcorcón, Alcorcón 28922, Madrid, Spain
Juan Carlos Trujillo-Reyes, Department of Thoracic Surgery, Hospital de la Santa Creu I Sant Pau, Barcelona 08029, Catalonia, Spain
Juan Carlos Trujillo-Reyes, Department of Surgery, Universitat Autonoma de Barcelona, Barcelona 08029, Catalonia, Spain
Felipe Couñago, Department of Radiation Oncology, Hospital Universitario Quirónsalud Madrid, Pozuelo de Alarcón 28223, Madrid, Spain
Felipe Couñago, Department of Radiation Oncology, Hospital La Luz, Madrid 28003, Spain
Felipe Couñago, Medicine Department, School of Biomedical Sciences, Universidad Europea de Madrid, Villaviciosa de Odón 28670, Madrid, Spain
Author contributions: Aguado C, Chara LE, Antoñanzas M, Matilla JM, Jiménez U and Hernanz R drafted the manuscript; Couñago F, Trujillo JC and Mielgo-Rubio X critically revised the content of the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests related to this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Carlos Aguado, MD, Consultant Physician-Scientist, Department of Medical Oncology, Hospital Clínico Universitario San Carlos, Calle del Prof Martín Lagos, s/n, Madrid 28040, Spain. carlos.aguado84@gmail.com
Received: April 28, 2021
Peer-review started: April 28, 2021
First decision: June 7, 2021
Revised: June 24, 2021
Accepted: May 7, 2022
Article in press: May 7, 2022
Published online: May 24, 2022
Peer-review started: April 28, 2021
First decision: June 7, 2021
Revised: June 24, 2021
Accepted: May 7, 2022
Article in press: May 7, 2022
Published online: May 24, 2022
Core Tip
Core Tip: Studies evaluating neoadjuvant immunotherapy in non-small cell lung cancer have reported extraordinary pathological response rates without any increase in postoperative complications. However, before immunotherapy is implemented in routine clinical practice, several issues still need to be resolved. This review analyses the current evidence for immunotherapy from a multidisciplinary perspective and discusses current and future controversies.