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World J Clin Oncol. Nov 24, 2022; 13(11): 866-879
Published online Nov 24, 2022. doi: 10.5306/wjco.v13.i11.866
Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis
Fabrício Freire de Melo, Hanna Santos Marques, Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Kádima Nayara Teixeira, Cláudio Lima Souza, Márcio Vasconcelos Oliveira
Fabrício Freire de Melo, Samuel Luca Rocha Pinheiro, Fabian Fellipe Bueno Lemos, Marcel Silva Luz, Cláudio Lima Souza, Márcio Vasconcelos Oliveira, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Brazil
Hanna Santos Marques, Campus Vitória da Conquista, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista 45029-094, Brazil
Kádima Nayara Teixeira, Campus Toledo, Universidade Federal do Paraná, Toledo 85919899, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version; all authors agree to be accountable for all aspects of the work in ensuring that questions that are related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Supported by National Council for Scientific and Technological Development, CNPq Brazil.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Fabrício Freire de Melo, PhD, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Estrada do Bem Querer, 3293-3391 - Candeias, Vitória da Conquista 45029-094, Brazil.
Received: August 6, 2022
Peer-review started: August 6, 2022
First decision: September 5, 2022
Revised: September 20, 2022
Accepted: October 11, 2022
Article in press: October 11, 2022
Published online: November 24, 2022
Processing time: 107 Days and 2.8 Hours
Core Tip

Core tip: CagA is a translocated effector protein that induces morphofunctional modifications in gastric epithelial cells and persistent chronic gastric inflammation. Upon translocation, the bacterial oncoprotein acts as a promiscuous scaffold or hub protein, which is capable of disrupting multiple host signaling pathways, thereby inducing precancerous cellular alterations. This review aims to describe Helicobacter pylori- and CagA-related oncogenic mechanisms, as well as to discuss the novelties and perspectives in this field.