Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2021; 12(9): 823-832
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.823
Features of primary pancreatic lymphoma: A bi-institutional review with an emphasis on typical and atypical imaging features
Nicole Segaran, Kumaresan Sandrasegaran, Catherine Devine, Mindy X Wang, Chintan Shah, Dhakshinamoorthy Ganeshan
Nicole Segaran, Kumaresan Sandrasegaran, Department of Radiology, Mayo Clinic Arizona, Phoenix, AZ 85054, United States
Catherine Devine, Mindy X Wang, Chintan Shah, Dhakshinamoorthy Ganeshan, Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States
Author contributions: Segaran N performed data analysis, and wrote the manuscript; Sandrasegaran K, and Ganeshan D designed the research, performed data collection and edited the manuscript; Shah C, and Devine C performed data collection and edited the manuscript; Wang MX contributed to study design and edited the manuscript.
Institutional review board statement: The study was reviewed and approved separately by the Institutional Review Boards of University of Texas MD Anderson Cancer and Mayo Clinic of Arizona.
Informed consent statement: As this is a retrospective review that involves no diagnostic or therapeutic intervention, as well as no direct patient contact, IRB permission was obtained with waiver of informed consent and waiver of authorization to use and review patient information.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data is available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dhakshinamoorthy Ganeshan, MD, Associate Professor, Department of Diagnostic Imaging, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, United States. dganeshan@mdanderson.org
Received: April 29, 2021
Peer-review started: April 29, 2021
First decision: June 16, 2021
Revised: June 29, 2021
Accepted: August 10, 2021
Article in press: August 10, 2021
Published online: September 24, 2021
Processing time: 140 Days and 18.2 Hours
Core Tip

Core Tip: Primary pancreatic lymphoma (PPL) is often misdiagnosed as pancreatic adenocarcinoma. This two-center retrospective study of twenty-nine cases emphasized computed tomography (CT) imaging features useful for distinguishing PPL from its mimics. Distinct CT features of PPL, including a large homogenous hypovascular mass, absence of ductal dilation or atrophy, encasement of mesenteric vessels without invasion, and the presence of small volume peripancreatic adenopathy, should alert the clinicians to the potential diagnosis of this rare neoplasm. This study also demonstrated atypical findings such as necrosis and mild pancreatic or biliary ductal dilation should not rule out the diagnosis of PPL.