Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2021; 12(9): 767-786
Published online Sep 24, 2021. doi: 10.5306/wjco.v12.i9.767
Re-irradiation for high-grade gliomas: Has anything changed?
Sonia García-Cabezas, Eleonor Rivin del Campo, Juan Solivera-Vela, Amalia Palacios-Eito
Sonia García-Cabezas, Amalia Palacios-Eito, Department of Radiation Oncology, Reina Sofia University Hospital, Cordoba 14004, Spain
Eleonor Rivin del Campo, Department of Radiation Oncology, Tenon University Hospital, Paris 75020, France
Juan Solivera-Vela, Department of Neurosurgery, Reina Sofia University Hospital, Cordoba 14004, Spain
Author contributions: All authors contributed to the writing and revision of this manuscript.
Conflict-of-interest statement: The authors have no conflict of interest related to the manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amalia Palacios-Eito, MD, PhD, Associate Professor, Chief Doctor, Department of Radiation Oncology, Reina Sofia University Hospital, Avda. Menéndez Pidal, s/n, Cordoba 14004, Spain. amalia.palacios.sspa@juntadeandalucia.es
Received: June 2, 2021
Peer-review started: June 2, 2021
First decision: July 16, 2021
Revised: July 21, 2021
Accepted: July 30, 2021
Article in press: July 30, 2021
Published online: September 24, 2021
Core Tip

Core Tip: The optimal management after recurrence or progression of high-grade gliomas is still undefined. Improved radiation therapy techniques, new imaging methods, published experience, as well as better radiobiological knowledge of the brain tissue have positioned re-irradiation as a valid alternative for many of these patients. Many questions remain unanswered. This review will focus on describing the most relevant studies that include re-irradiation as salvage treatment, with the aim of simplifying decision-making and designing the best available therapeutic strategy.