Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2021; 12(2): 95-102
Published online Feb 24, 2021. doi: 10.5306/wjco.v12.i2.95
Autosegmentation of cardiac substructures in respiratory-gated, non-contrasted computed tomography images
Mark Farrugia, Han Yu, Anurag K Singh, Harish Malhotra
Mark Farrugia, Anurag K Singh, Harish Malhotra, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, United States
Han Yu, Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, United States
Author contributions: Farrugia M participated in conceptualization, manual contouring, data analysis, figure construction, writing and editing; Yu H provided statistical support and review; Singh AK was involved in conceptualization and supervision; Malhotra H participated in conceptualization, supervision, software utilization, writing and editing.
Institutional review board statement: The study was reviewed and approved by the Roswell Park Comprehensive Cancer Center Institutional Review Board, No. EDR 171710.
Institutional animal care and use committee statement: The current project did not require any work with animal subjects.
Conflict-of-interest statement: No author claims any conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Harish Malhotra, PhD, Assistant Professor, Department of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY 14203, United States.
Received: November 20, 2020
Peer-review started: November 20, 2020
First decision: December 3, 2020
Revised: December 7, 2020
Accepted: December 22, 2020
Article in press: December 22, 2020
Published online: February 24, 2021
Core Tip

Core Tip: Autosegmentation is an attractive tool to reduce the labor involved with manual delineation of anatomy. However, it is unclear whether this approach is viable for all treatment conditions. Stereotactic body radiation therapy frequently utilizes respiratory gated, non-contrasted computed tomography imaging for radiation planning and involuntary heart motion as well as lack of intravenous contrast may impact the quality of generated structures. In our study, MIM software successfully contoured the great vessels and heart chambers yet failed in generating coronary arteries. We provide evidence that MIM software can reliably autocontour the larger cardiac substructures, but not coronary arteries or heart valves.