Retrospective Cohort Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Sep 24, 2020; 11(9): 747-760
Published online Sep 24, 2020. doi: 10.5306/wjco.v11.i9.747
Comparison of efficacy between adjuvant chemotherapy and chemoradiation therapy for pancreatic cancer: AJCC stage-based approach
Min Su You, Ji Kon Ryu, Gunn Huh, Jung Won Chun, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim
Min Su You, Ji Kon Ryu, Gunn Huh, Jung Won Chun, Woo Hyun Paik, Sang Hyub Lee, Yong-Tae Kim, Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul 110-744, South Korea
Author contributions: You MS and Ryu JK contributed to the conceptualization and methodology; You MS contributed to data collection; Huh G, Chun JW and Paik WH contributed to collect resources; Lee SH and Kim YT contributed to supervision; You MS and Ryu JK contributed to manuscript writing; Huh G and Ryu JK contributed to critical revision; all authors read and approved the final manuscript.
Supported by Seoul National University College of Medicine Research Fund (2017).
Institutional review board statement: This study was approved by Institutional Review Board of the Seoul National University Hospital, Seoul, South Korea (1609-015-789).
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: Data are available from the corresponding author on a reasonable request.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ji Kon Ryu, MD, PhD, Doctor, Professor, Internal Medicine and Liver Research Institute, Seoul National University Hospital, 101 Daehangno, Chongno-gu, Seoul 110-744, South Korea. jkryu@snu.ac.kr
Received: April 3, 2020
Peer-review started: April 3, 2020
First decision: April 18, 2020
Revised: August 5, 2020
Accepted: August 24, 2020
Article in press: August 24, 2020
Published online: September 24, 2020
Core Tip

Core Tip: We retrospectively reviewed 335 patients who underwent surgical resection and adjuvant treatment for pancreatic cancer. Patients were divided into three groups; chemoradiation therapy (CRT), systemic chemotherapy (SCT) and CRT-SCT. In patients with stage III cancer, median overall survival in the SCT and CRT-SCT groups was significantly longer than that in the CRT group. On the other hand, there was no significant difference in overall survival between CRT, SCT and CRT-SCT in those with stage I/II. SCT with or without CRT might be a reasonable choice preferentially over CRT in patients with American Joint Committee on Cancer stage III.