Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Aug 24, 2020; 11(8): 573-588
Published online Aug 24, 2020. doi: 10.5306/wjco.v11.i8.573
Statins in risk-reduction and treatment of cancer
Cristina I Barbalata, Lucia R Tefas, Marcela Achim, Ioan Tomuta, Alina S Porfire
Cristina I Barbalata, Lucia R Tefas, Marcela Achim, Ioan Tomuta, Alina S Porfire, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu-Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca 400012, Romania
Author contributions: Barbalata CI wrote the manuscript with support from Tefas LR, Achim M and Porfire AS; Porfire AS and Barbalata CI conceived the idea and organized the manuscript; Porfire AS and Tomuta I supervised the project and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Alina S Porfire, PhD, Associate Professor, Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, “Iuliu- Hatieganu” University of Medicine and Pharmacy, 41 Victor Babes, Cluj-Napoca 400012, Romania. aporfire@umfcluj.ro
Received: February 28, 2020
Peer-review started: February 28, 2020
First decision: April 29, 2020
Revised: May 18, 2020
Accepted: June 10, 2020
Article in press: June 10, 2020
Published online: August 24, 2020
Core Tip

Core tip: In the last few years, statins have been increasingly studied for their anticancer properties. This review presents the application of statins in cancer management by outlining the latest in vitro and in vivo studies. The results represent the foundation of the latest clinical trials in order to search for new treatment directions in cancer therapy.