Copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Feb 24, 2020; 11(2): 103-109
Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.103
Published online Feb 24, 2020. doi: 10.5306/wjco.v11.i2.103
Metastatic clear cell renal cell carcinoma in isolated retroperitoneal lymph node without evidence of primary tumor in kidneys: A case report
Lisa BE Shields, Norton Neuroscience Institute, Norton Healthcare, Louisville, KY 40202, United States
Arash Rezazadeh Kalebasty, Norton Cancer Institute, Norton Healthcare, Louisville, KY 40202, United States
Author contributions: Shields LB and Kalebasty AR contributed to the conception, design, acquisition, analysis, and interpretation of data; Shields LB drafted the manuscript; Shields LB and Kalebasty AR critically revised the manuscript and gave final approval.
Informed consent statement: The patient gave written informed consent for the publication of this case.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Arash Rezazadeh Kalebasty, MD, Norton Cancer Institute, Norton Healthcare, 315 East Broadway, Louisville, KY 40202, United States. arash.rezazadehkalebasty@nortonhealthcare.org
Received: October 18, 2019
Peer-review started: October 18, 2019
First decision: November 5, 2019
Revised: November 8, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: February 24, 2020
Peer-review started: October 18, 2019
First decision: November 5, 2019
Revised: November 8, 2019
Accepted: November 29, 2019
Article in press: November 29, 2019
Published online: February 24, 2020
Core Tip
Core tip: Retroperitoneal lymph node dissection has important diagnostic, therapeutic, and prognostic functions in renal cell carcinoma (RCC). We present the first case of a solitary metastatic retroperitoneal lymph node with an unknown primary site but whose immunohistochemical features were consistent with clear cell RCC (CCRCC). A nephrectomy was not performed as a renal mass was not detected on any prior radiological examinations. Imaging studies for a subsequent 5 years demonstrated no recurrent or metastatic disease or retroperitoneal adenopathy. Our case highlights the therapeutic role of metastasectomy in metastatic CCRCC in the absence of a primary tumor in the kidneys.