Minireviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Dec 24, 2020; 11(12): 1008-1017
Published online Dec 24, 2020. doi: 10.5306/wjco.v11.i12.1008
Fluoropyrimidine-induced cardiotoxicity
Andrada Larisa Deac, Claudia Cristina Burz, Ioana Corina Bocsan, Anca Dana Buzoianu
Andrada Larisa Deac, Department of Medical Oncology, "Prof.Dr.Ion Chiricuta" Oncology Institute from Cluj-Napoca, Cluj-Napoca 400015, Cluj, Romania
Claudia Cristina Burz, Department of Immunology and Allergology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca 400015, Cluj, Romania
Ioana Corina Bocsan, Anca Dana Buzoianu, Department of Pharmacology, Toxicology and Clinical Pharmacology, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca 400015, Cluj, Romania
Author contributions: Deac AL performed the majority of the writing, designed the tables and figures; Deac AL, Burz CC, Bocsan IC, Buzoianu AD designed the study; Deac AL performed the research on medical literature; all authors have read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Andrada Larisa Deac, MD, Doctor, Department of Medical Oncology, "Prof.Dr.Ion Chiricuta" Oncology Institute from Cluj-Napoca, Republicii Street, Cluj-Napoca 400015, Cluj, Romania. andrada.deac@gmail.com
Received: June 8, 2020
Peer-review started: June 8, 2020
First decision: September 18, 2020
Revised: September 27, 2020
Accepted: October 20, 2020
Article in press: October 20, 2020
Published online: December 24, 2020
Core Tip

Core Tip: There are several reviews and cases which showed fluoropyrimidine-induced cardiotoxicity. However, this mini-review includes useful information on clinical manifestations, pathophysiological mechanisms, diagnosis, and management of fluoropyrimidine-induced cardiotoxicity.