Systematic Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Oncol. Jan 24, 2020; 11(1): 31-42
Published online Jan 24, 2020. doi: 10.5306/wjco.v11.i1.31
Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review
Rogelio González-González, Sandra López-Verdín, Jesús Lavalle-Carrasco, Nelly Molina-Frechero, Mario Isiordia-Espinoza, Ramón G Carreón-Burciaga, Ronell Bologna-Molina
Rogelio González-González, Jesús Lavalle-Carrasco, Ramón G Carreón-Burciaga, Department of Research, School of Dentistry, Universidad Juárez del Estado de Durango, Durango 34000, Mexico
Sandra López-Verdín, Research Institute of Dentistry, Health Science Center, Universidad de Guadalajara, Guadalajara 4430, Mexico
Nelly Molina-Frechero, Department of Health Care, Xochimilco Unit, Universidad Autónoma Metropolitana Xochimilco, México 04960, Mexico
Mario Isiordia-Espinoza, Department of Clinics, Biomedical Sciences Division, Centro Universitario de los Altos, Universidad de Guadalajara, Tepetitlán de Morelos 47620, Mexico
Ronell Bologna-Molina, Molecular Pathology Area, School of Dentistry, Universidad de la República, Montevideo 11600, Uruguay
Author contributions: González-González R and Bologna-Molina R conceived and design the study, review the manuscripts selected, drafted and review the manuscript, López-Verdín S and Carreón-Burciaga RG made the bibliographic research, and review the manuscript, Lavalle-Carrasco J design the study, drafted and review the manuscript, Molina-Frechero N and Isiordia-Espinoza M made the bibliographic research and review the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
PRISMA 2009 Checklist statement: This study followed PRISMA guidelines in its performing, and PRISMA 2009 checklist was attached, this study does not evaluate biostatistical and different modalities treatments, only few targeted therapies reported cases.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Ronell Bologna-Molina, DDS, MSc, PhD, Molecular Pathology Area, School of Dentistry, Universidad de la República, Las Heras 1925, Montevideo 11600, Uruguay. ronellbologna@odon.edu.uy
Received: March 25, 2019
Peer-review started: March 26, 2019
First decision: September 2, 2019
Revised: October 23, 2019
Accepted: November 6, 2019
Article in press: November 6, 2019
Published online: January 24, 2020
Core Tip

Core tip: Ameloblastoma is a common neoplasia that is developed from odontogenic epithelium. It is an aggressive and recurrent tumor that can present metastases or malignant transformation. This neoplasia is characterized by presenting different clinical and histological varieties as well as several mutations related to its behavior. Nowadays, there are several studies focused on targeted therapies against the mutations of this tumor, one of the most frequent ones being B-raf proto-oncogene serine/threonine kinase (BRAF) V600E, the treatment of which has been associated with good response. These targeted therapies are suitable for resistant tumors. This study focused on BRAF V600E mutations and its additional mutations and targeted therapies.