Published online Oct 10, 2017. doi: 10.5306/wjco.v8.i5.425
Peer-review started: December 5, 2016
First decision: February 17, 2017
Revised: July 24, 2017
Accepted: August 15, 2017
Article in press: August 16, 2017
Published online: October 10, 2017
Charcot-Marie-Tooth (CMT) neuropathy is the most common hereditary cause of neuropathy. Diagnosis is usually not made during the childhood but in adolescence or late adulthood. It is reported in the literature that some neurotoxic chemotherapeutical agents can reveal an asymptomatic CMT IA hereditary neuropathy. To our knowledge, we report here the first case of CMT IA revealed in a 55-year-old woman after the administration of docetaxel/trastuzumab/pertuzumab for metastatic breast cancer. This case stresses again the necessity to obtain a complete personal and familial anamnesis and to perform a neurologic examination before the administration of neurotoxic chemotherapeutical agents to prevent the clinical expression of these hereditary neuropathies.
Core tip: This case report represents the first case of Charcot-Marie-Tooth IA revealed after the administration of docetaxel/trastuzumab/pertuzumab for metastatic breast cancer. This paper will help to focus on the revelation of rare hereditary neuropathies after the administration of chemotherapies.