Montminy EM, Landreneau SW, Karlitz JJ. First report of small cell lung cancer with PTHrP-induced hypercalcemic pancreatitis causing disconnected duct syndrome. World J Clin Oncol 2017; 8(5): 420-424 [PMID: 29067279 DOI: 10.5306/wjco.v8.i5.420]
Corresponding Author of This Article
Eric M Montminy, MD, Internal Medicine Resident, Tulane University Medical Center, 1430 Tulane Avenue, SL-50, New Orleans, LA 70112, United States. emontmin@tulane.edu
Research Domain of This Article
Oncology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Oct 10, 2017; 8(5): 420-424 Published online Oct 10, 2017. doi: 10.5306/wjco.v8.i5.420
First report of small cell lung cancer with PTHrP-induced hypercalcemic pancreatitis causing disconnected duct syndrome
Eric M Montminy, Stephen W Landreneau, Jordan J Karlitz
Eric M Montminy, Jordan J Karlitz, Division of Gastroenterology, Tulane University Medical Center, New Orleans, LA 70112, United States
Stephen W Landreneau, Division of Gastroenterology, LSU Health Sciences Center, New Orleans, LA 70112, United States
Author contributions: Montminy EM and Landreneau SW wrote manuscript and directly cared for the patient while hospitalized; Karlitz JJ was overseeing author and provided edits to manuscript.
Informed consent statement: The patient discussed in this case report gave written consent to share imaging and discuss his medical information. This consent was witnessed.
Conflict-of-interest statement: All authors had no conflicts of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Eric M Montminy, MD, Internal Medicine Resident, Tulane University Medical Center, 1430 Tulane Avenue, SL-50, New Orleans, LA 70112, United States. emontmin@tulane.edu
Telephone: +1-630-3060555 Fax: +1-504-9883971
Received: June 2, 2017 Peer-review started: June 6, 2017 First decision: June 27, 2017 Revised: July 5, 2017 Accepted: August 16, 2017 Article in press: August 17, 2017 Published online: October 10, 2017
Abstract
Here we report a patient diagnosed with small cell lung cancer after first presenting with parathyroid hormone-related peptide-induced hypercalcemic pancreatitis and developed walled-off necrosis that resulted in disruption of the main pancreatic duct. Disconnected duct syndrome (DDS) is a rare syndrome that occurs when the main pancreatic duct exocrine flow is disrupted resulting in leakage of pancreatic enzymes and further inflammatory sequela. To date, no prior reports have described DDS occurring with paraneoplastic reactions. Diagnostic imaging techniques and therapeutic interventions are reviewed to provide insight into current approaches to DDS.
Core tip: Acute recurrent pancreatitis flares should raise concern for disconnected duct syndrome (DDS). This case is the first reported case of DDS caused by paraneoplastic hypercalcemia. Paraneoplastic syndromes may predispose patients to prolonged hypercalcemic pancreatitis and in turn, may predispose patients to DDS. Furthermore, this case report reviews the current approach and treatment difficulties of DDS as well as pancreatic walled-off necrosis.
