Wu ZL, Wang Y, Jia XY, Wang YG, Wang H. Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers. World J Clin Oncol 2024; 15(5): 603-613 [PMID: 38835843 DOI: 10.5306/wjco.v15.i5.603]
Corresponding Author of This Article
Yi-Gang Wang, PhD, Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928 2nd Street, Qiantang District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. May 24, 2024; 15(5): 603-613 Published online May 24, 2024. doi: 10.5306/wjco.v15.i5.603
Receptor tyrosine kinase-like orphan receptor 1: A novel antitumor target in gastrointestinal cancers
Zheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Hui Wang
Zheng-Long Wu, Ying Wang, Xiao-Yuan Jia, Yi-Gang Wang, Xinyuan Institute of Medicine and Biotechnology, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, Zhejiang Province, China
Zheng-Long Wu, Hui Wang, Department of Oncology, Zhejiang Xiaoshan Hospital, Hangzhou 311201, Zhejiang Province, China
Author contributions: Wu ZL performed the majority of the writing, prepared the figures and tables; Wang Y coordinated the writing of the paper Wang H provided the input in writing the paper; Jia XY and Wang YG contributed to the conception and design of the paper, literature review, critical revision and approval of the final version.
Supported bythe Hangzhou Medical Health Science and Technology Project, No. B20220173; the Public Welfare Technology Project of Zhejiang Province, No. LGF21H160033; and Zhejiang Medical Technology Plan Project, No. 2021KY047.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Gang Wang, PhD, Professor, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928 2nd Street, Qiantang District, Hangzhou 310018, Zhejiang Province, China. wangyigang43@163.com
Received: January 3, 2024 Revised: March 20, 2024 Accepted: April 17, 2024 Published online: May 24, 2024
Abstract
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the type I receptor tyrosine kinase family. ROR1 is pivotal in embryonic development and cancer, and serves as a biomarker and therapeutic target. It has soluble and membrane-bound subtypes, with the latter highly expressed in tumors. ROR1 is conserved throughout evolution and may play a role in the development of gastrointestinal cancer through multiple signaling pathways and molecular mechanisms. Studies suggest that overexpression of ROR1 may increase tumor invasiveness and metastasis. Additionally, ROR1 may regulate the cell cycle, stem cell characteristics, and interact with other signaling pathways to affect cancer progression. This review explores the structure, expression and role of ROR1 in the development of gastrointestinal cancers. It discusses current antitumor strategies, outlining challenges and prospects for treatment.
Core Tip: Delve into a comprehensive review spotlighting receptor tyrosine kinase-like orphan receptor 1 (ROR1) pivotal involvement in gastrointestinal cancer advancement and its promising prospects as an anti-tumor remedy. Explore pivotal cellular pathways governing ROR1 regulation and pertinent insights into existing commercial therapeutic offerings. Emphasizing ROR1’s crucial role in gastrointestinal cancer treatment, this review offers a nuanced blend of historical context and scientific insight, illuminating the dynamic landscape of this evolving field.
