Wu T, Ji MR, Luo LX. Mechanisms and potential applications of COPS6 in pan-cancer therapy. World J Clin Oncol 2024; 15(3): 367-370 [PMID: 38576589 DOI: 10.5306/wjco.v15.i3.367]
Corresponding Author of This Article
Lian-Xiang Luo, PhD, Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn
Research Domain of This Article
Cell Biology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Oncol. Mar 24, 2024; 15(3): 367-370 Published online Mar 24, 2024. doi: 10.5306/wjco.v15.i3.367
Mechanisms and potential applications of COPS6 in pan-cancer therapy
Tong Wu, Miao-Rong Ji, Lian-Xiang Luo
Tong Wu, Miao-Rong Ji, The First Clinical College, Guangdong Medical University, Zhanjiang 524023, Guangdong Province, China
Lian-Xiang Luo, The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524000, Guangdong Province, China
Author contributions: Luo LX conceived and designed the editorial; Wu T and Ji MR wrote the editorial; Luo LX reviewed the paper and provided comments; All authors read and approved the final manuscript.
Conflict-of-interest statement: All authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lian-Xiang Luo, PhD, Associate Professor, The Marine Biomedical Research Institute, Guangdong Medical University, No. 2 Wenming East Road, Xiashan District, Zhanjiang 524000, Guangdong Province, China. luolianxiang321@gdmu.edu.cn
Received: November 2, 2023 Peer-review started: November 2, 2023 First decision: December 31, 2023 Revised: January 11, 2024 Accepted: February 4, 2024 Article in press: February 4, 2024 Published online: March 24, 2024
Abstract
The COP9 signalosome subunit 6 (COPS6) is abnormally overexpressed in many malignancies, yet its precise role in carcinogenesis is unknown. To gain a better understanding of COPS6's role, the authors conducted a pan-cancer analysis using various bioinformatics techniques such as differential expression patterns, prognostic value, gene mutations, immune infiltration, correlation analysis, and functional enrichment assessment. Results showed that COPS6 was highly correlated with prognosis, immune cell infiltration level, tumor mutation burden, and microsatellite instability in patients with a range of tumor types. This suggests that COPS6 may be a potential target for cancer treatment. Overall, this research provides insight into COPS6's role in cancer development and its potential therapeutic applications.
Core Tip: COPS6 expression is often increased in malignancies, and this is associated with a poor prognosis, suggesting that it could be a potential biomarker for tumors. However, the exact role of COPS6 in different types of tumors is still unknown. This research seeks to investigate the expression of COPS6 in various tumor tissues, its prognostic value, mutations in the gene, and the correlation between expression levels and immune infiltration with different types of immune cells.
