Retrospective Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pharmacol Ther. May 6, 2018; 9(2): 16-21
Published online May 6, 2018. doi: 10.4292/wjgpt.v9.i2.16
Hypothyroidism in patients with autoimmune pancreatitis
Ryoko Shimizuguchi, Terumi Kamisawa, Yuka Endo, Masataka Kikuyama, Sawako Kuruma, Kazuro Chiba, Taku Tabata, Satomi Koizumi
Ryoko Shimizuguchi, Terumi Kamisawa, Yuka Endo, Masataka Kikuyama, Sawako Kuruma, Kazuro Chiba, Taku Tabata, Satomi Koizumi, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo 113-8677, Japan
Author contributions: All authors helped to perform the research; Shimizuguchi R and Kamisawa T wrote manuscript, collected and analyzed data; Endo Y, Kikuyama M, Kuruma S, Chiba K, Tabata T and Koizumi S collected data.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Tokyo Metropolitan Komagome Hospital.
Informed consent statement: This study is a retrospective our using information that had been obtained according to comprehensive agreement.
Conflict-of-interest statement: All authors declare no conflict-of-interest related to this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Terumi Kamisawa, MD, PhD, Chief Doctor, Department of Internal Medicine, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Tokyo 113-8677, Japan. kamisawa@cick.jp
Telephone: +81-3-38232101 Fax: +81-3-38235433
Received: November 27, 2017
Peer-review started: November 28, 2017
First decision: January 2, 2018
Revised: January 19, 2018
Accepted: March 6, 2018
Article in press: March 7, 2018
Published online: May 6, 2018
Core Tip

Core tip: Autoimmune pancreatitis (AIP) is a pancreatic manifestation of IgG4-related disease (IgG4-RD) and is frequently associated with other IgG4-RDs. The aim of this study was to examine thyroid function and clinical features of hypothyroidism in AIP patients. Hypothyroidism was observed in 8 (10%) of 77 AIP patients and was subclinical in 6 patients and central in 2 patients. After steroid therapy, both subclinical and central hypothyroidism improved with improvement of the AIP.