Copyright ©The Author(s) 2015.
World J Gastrointest Pathophysiol. Feb 15, 2015; 6(1): 13-22
Published online Feb 15, 2015. doi: 10.4291/wjgp.v6.i1.13
Table 1 Main biological markers in ulcerative colitis
Serum markers of acute phase responseResponse
C-reactive proteinIncreased
Erithrocyte sedimentation rateIncreased
Platelet countIncreased
White blood cell countIncreased
Alpha1-acid glycoprotein (Oromucoid)Increased
Sialic acidIncreased
Serum amyloid AIncreased
Serum albuminComplement systemDecreased
TrasferrinComplement systemDecreased
C1s, C2, C3, C4, BComplement systemIncreased
HaptogloginTransport proteinsIncreased
HaemopexinTransport proteinsIncreased
CaeruloplasminTransport proteinsIncreased
Alpha1 AntitrypsinProteinase inhibitorsIncreased
Alpha 1 antichymotrypsinProteinase inhibitorsIncreased
FibrinogenCoagulation and fibrinolytic proteinsIncreased
ProthrombinCoagulation and fibrinolytic proteinsIncreased
PlasminogenCoagulation and fibrinolytic proteinsIncreased
Factor XIICoagulation and fibrinolytic proteinsDecreased
IL-6, IL-1 β- TNF-α, IL-8, IL-10, Interferon-βCytokinesIncreased
Serologic markers/antibodiesPositive rate
ANCAsAnti-neutrophil cytoplasmic antibodies (cANCA, sANCA, pANCA)2%-28% CD
20%-85% UC
ASCAAnti-saccharomyces cerevisiae antibodies39%-69% CD
5%-15% UC
Anti-OmpCAntibodies to outer membrane porin24%-50% CD
5%-11% UC
Anti-Cbir1Flagellin related antigen50% CD
5%-11% UC
Anti-I2Pseudomonas flourescens-associated sequence I-230%-50% CD
2%-10% UC
Flagellin A4-Fla2 and Fla-X antibodiesNewly identifiedAbout 57% CD
Antilaminaribioside carbohydrate IgG (ALCA)Antiglycan antibody17%-28% CD
4%-7% UC
Antichitobioside carbohydrate IgA (ACCA)Antiglycan antibody20%-25% CD
5%-15% UC
Anti-synthetic mannoside antibodies (ASMA or AMCA)Antiglycan antibody28% CD
18% UC
Pancreatic antibodiesPancreatic secretion30%-40% CD
2%-6% UC
Serum p53 antibodies9.3% UC