Letters To The Editor Open Access
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World J Gastrointest Pathophysiol. Nov 15, 2014; 5(4): 589-590
Published online Nov 15, 2014. doi: 10.4291/wjgp.v5.i4.589
Antiviral treatment in patients with cytomegalovirus positive ulcerative colitis
Kadir Ozturk, Department of Gastroenterology, Gulhane School of Medicine, GATA Gastroenteroloji BD, Etlik, 06010 Ankara, Turkey
Author contributions: Ozturk K contributed to the paper.
Correspondence to: Kadir Ozturk, MD, PhD, Department of Gastroenterology, Gulhane School of Medicine, GATA Gastroenteroloji BD, General Tevfik Saglam Street, Etlik, 06010 Ankara, Turkey. kadirozturk3041@gmail.com
Telephone: +90-312-3044047 Fax: +90-312-3044045
Received: May 6, 2014
Revised: June 29, 2014
Accepted: September 16, 2014
Published online: November 15, 2014

Abstract

Cytomegalovirus (CMV) is a common virus in patients with ulcerative colitis receiving immunosuppressive drugs. Many studies suggested that CMV infection is an exacerbating factor in patients with ulcerative colitis. The role of CMV in exacerbations of ulcerative colitis has been discussed. One of studies starting this discussion is an article entitled “CMV positive ulcerative colitis: A single center experience and literature review” by Kopylov et al. However, we think that there are some points that should be emphasized about the study. Especially, the small number of patients in the study has led to meaningless results. Large controlled prospective trials are needed to clarify the benefit of antiviral therapy for active ulcerative colitis patients.

Key Words: Cytomegalovirus, Ulcerative colitis, Antiviral treatment, Steroid resistant, Colonoscopy

Core tip: Many studies suggested that cytomegalovirus (CMV) infection is an exacerbating factor in patients with ulcerative colitis. The role of CMV in exacerbations of ulcerative colitis has been discussed. We believe that large controlled prospective trials are needed to clarify the benefit of antiviral therapy for active ulcerative colitis patients.



TO THE EDITOR

We read with great interest the recently published article entitled “Cytomegalovirus (CMV) positive ulcerative colitis: A single center experience and literature review” by Kopylov et al[1] in the February 15, 2013 issue of World Journal of Gastrointestinal Pathophysiology. In this retrospective study, the authors compared the clinical outcomes of CMV-positive ulcerative colitis patients with and without antiviral therapy (gancyclovir). They concluded that patients with obvious histological evidence of CMV in the colonic mucosa may not universally require antiviral therapy and may respond to conventional anti-inflammatory therapy. This study reveals the indications for antiviral therapy in CMV-positive patients with ulcerative colitis. Moreover, it provides some new information that represents educational “take-home messages” for readers. We believe that further studies will be performed in light of these findings. However, we think that there are some points that should be emphasized about the study.

First, in the discussion section of the paper, the authors reported that patients in the antiviral-treated group “are in greater need of hospitalization” than patients without antiviral treatment. However, as shown in Table 1, no statistically significant difference could be seen between these two groups. As we know that the P value is revealed below a certain significance level, often 0.05, this elucidates a strong presumption against the null hypothesis[2,3]. In light of this, we suggest that the conclusion of the present study should be reviewed.

Table 1 Clinical and demographic characteristics of the included patients (mean ± SD).
Patient characteristicTreated (n = 7)Untreated (n = 6)P value
Age (yr)50.0 ± 14.645.0 ± 13.60.540
Gender (male/female)4/33/30.400
Extent of disease
Pancolitis650.540
Left-sided110.540
Age at diagnosis of UC, yr35.7 ± 13.341.5 ± 13.30.530
Duration of disease, yr14.2 ± 9.33.5 ± 1.80.008
Hospitalized patients640.560
Prehospitalization treatment
SC420.560
Thiopurines321.000
Infliximab1101.000
5-asa541.000
SC + thiopurines211.000
Treatment during hospitalization
SC630.400
Infliximab101.000
Cyclosporine300.200
Timing of colonoscopy (d)3.8 ± 2.42.7 ± 3.40.600
Positive cytopathic changes on HE staining200.460
Hospitalization outcome
Death101.000
Colectomy101.000
Outcome by the end of the follow-up
Colectomy300.190
Death101.000

Second, the authors mentioned in the discussion section that only three patients without antiviral therapy were hospitalized. However, four patients in the group without antiviral therapy were hospitalized, according to Table 1. Finally, there are conflicting data regarding the staining method of the histopathological examination. Consequently, we conclude that, before making certain interpretations, this work should be rearranged in light of the above-mentioned suggestions. This could provide the readers of the journal clearer information regarding the role of CMV infection in the pathogenesis and clinical course of ulcerative colitis.

Footnotes

P- Reviewer: Ahluwalia NK, El-Tawil AM, Kawasaki H, Nevels M S- Editor: Ji FF L- Editor: Wang TQ E- Editor: Wang CH

References
1.  Kopylov U, Sasson G, Geyshis B, Oikawa MT, Barshack I, Eliakim R, Ben-Horin S. Cytomegalovirus positive ulcerative colitis: A single center experience and literature review. World J Gastrointest Pathophysiol. 2013;4:18-23.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in CrossRef: 14]  [Cited by in F6Publishing: 16]  [Article Influence: 1.5]  [Reference Citation Analysis (0)]
2.  Stigler S. Fisher and the 5% level. Chance. 2008;21:12.  [PubMed]  [DOI]  [Cited in This Article: ]
3.  Goodman SN. Toward evidence-based medical statistics. 2: The Bayes factor. Ann Intern Med. 1999;130:1005-1013.  [PubMed]  [DOI]  [Cited in This Article: ]  [Cited by in Crossref: 606]  [Cited by in F6Publishing: 518]  [Article Influence: 20.7]  [Reference Citation Analysis (0)]