Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastrointest Pathophysiol. May 15, 2014; 5(2): 107-113
Published online May 15, 2014. doi: 10.4291/wjgp.v5.i2.107
Table 1 Role of gamma-delta T cells in human and experimental liver disease
SpeciesLiver diseaseTCR usageCytokine productionOther markersEffector function(s)Ref.
Protective functions of γδ T cells
MouseConcanavalin A-induced hepatitisVγ4IL-17γδ T cells inhibit NKT cell function[20]
MouseExperimental fibrosisVγ4?IL-17, IL-22CCR6, CD95Lγδ T cells induce stellate cell apoptosis and limit collagen production[47]
MouseListeria monocytogenes infectionVγ4IL-10γδ T cells downregulate CD8+ T cell effector function[39]
Vγ4/Vγ6IL-17γδ T cells are protective during early infection[24]
HumanLiver metastasis of colon cancerVδ1IFNγ, TNFα, IL-2CD56, CD161hepatic γδ T cells are cytotoxic against tumor cell lines in culture[17]
HumanPediatric tumor cell cultureVγ9Vδ2?γδ T cells are cytotoxic against hepatoma cells in culture[18]
MouseAdenoviral infectionVγ4IL-17γδ T cells are critical for establishment of functional adaptive immune responses[21]
Pathogenic functions of γδ T cells
MouseSchistosoma japonicum infection?IL-17γδ T cells contribute to immune-mediated pathology[40]
MouseAdenoviral infection?IFN-γCXCR3γδ T cells contribute to hepatocyte apoptosis via FasL engagement and recruitment of cytotoxic T cells[37]
MouseMHV infection?TNF-α, IFN-γ, IL-17, IL-2CD69, CD44γδ T cells induce hepatocyte apoptosis via TNF-α-signaling[38]
HumanHCV infectionVδ1IFN-γHLA-DR, CD95, CD45-ROActivated γδ T cells contribute to HCV-mediated immunopathology[19]