Published online May 15, 2014. doi: 10.4291/wjgp.v5.i2.107
Revised: February 4, 2014
Accepted: March 13, 2014
Published online: May 15, 2014
Core tip: The liver is particularly enriched in unconventional T cells expressing the gamma-delta T cell receptor and the functional role of these gamma-delta (γδ) T cells in liver diseases is being intensively investigated at present. γδ T cells accumulate in inflamed liver and their function appears highly dependent on the distinct subsets. In principle, γδ T cells can be protective as well as pathogenic in the context of liver inflammation. This review summarizes the current knowledge of γδ T cell effector functions and the cytokines produced by these cells in human liver diseases and murine experimental models of acute and chronic liver injury.