Elusive liver factor that causes pancreatic α cell hyperplasia: A review of literature

Figure 1 Realtime polymerase chain reaction of several genes differentially expressed in the Gcgr^-/- mice. See text for details.

Figure 2 Schematic drawing of regulation of pancreatic α cell number by a humoral liver factor. The numbers indicate specific ways to disrupt glucagon signaling. (1) Glucagon deletion; (2) PC2 deletion; (3) Glucagon receptor (Gcgr) global deletion; (4) Gcgr liver-specific deletion; (5) Gcgr inactivating mutation; (6) Gcgr antisense RNA; (7) Gcgr antagonists; (8) Gcgr antibodies; and (9) Gsa liver-specific deletion. See text for details.