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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Aug 15, 2017; 8(3): 117-126
Published online Aug 15, 2017. doi: 10.4291/wjgp.v8.i3.117
Published online Aug 15, 2017. doi: 10.4291/wjgp.v8.i3.117
Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers
Brian K McFarlin, Andrea L Henning, Erin M Bowman, Melody A Gary, Applied Physiology Laboratory, University of North Texas, Denton, TX 76203, United States
Brian K McFarlin, Andrea L Henning, Kimberly M Carbajal, Department of Biological Sciences, University of North Texas, Denton, TX 76203, United States
Author contributions: McFarlin BK designed the study, collected data, interrupted findings, and prepared manuscript; Henning AL, Bowman EM, Gary MA and Carbajal KM collected data, interrupted findings, and prepared manuscript.
Institutional review board statement: The study was reviewed and approved by the UNT Institutional Review Board for Human Subjects Research.
Informed consent statement: Subjects provided written and oral consent to participate using an IRB-approved informed consent form specific to the study in question.
Conflict-of-interest statement: The present study was funded in part by a competitive research grant from Microbiome Labs, LLC (Glenview, IL) to the University of North Texas. The UNT team did not receive direct funding associated with the completion of the present study. The funding agency was not involved in the data collection, analysis, interpretation, and manuscript preparation. Double blind procedures and confidentially were used to conduct the present study in a sound and unbiased manner. As such, the authors report no conflict of interest associated with completing the present study.
Data sharing statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Brian K McFarlin, PhD, FACSM, FTOS, Associate Professor, Applied Physiology Laboratory, University of North Texas, 1921 West Chestnut Street, PEB Room 209, Denton, TX 76203, United States. brian.mcfarlin@unt.edu
Telephone: +1-940-5653165 Fax: +1-940-5654904
Received: January 26, 2017
Peer-review started: February 8, 2017
First decision: April 17, 2017
Revised: July 4, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: August 15, 2017
Peer-review started: February 8, 2017
First decision: April 17, 2017
Revised: July 4, 2017
Accepted: July 14, 2017
Article in press: July 17, 2017
Published online: August 15, 2017
Core Tip
Core tip: Dietary or metabolic endotoxemia is a condition that affects approximately 1/3 of individuals living in Western society. It is characterized by increased serum endotoxin concentration during the first five hours of the post-prandial period following consumption of a meal with a high-fat, high-calorie content. The key findings of the present study, were that 30-d of oral spore-based probiotic supplementation reduced the incidence of dietary endotoxemia, which may be indicative of reduced gut permeability.