Published online Feb 15, 2016. doi: 10.4291/wjgp.v7.i1.27
Peer-review started: September 2, 2015
First decision: September 29, 2015
Revised: November 13, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: February 15, 2016
Core tip: Proteomic methods provide a powerful tool that can be applied to the discovery of disease markers, allowing for rapid identification and quantification of proteins. Inflammatory bowel disease (IBD) currently faces many challenges, ranging from the elucidation of its pathophysiology to the accurate diagnosis in patients. Proteomics has been widely employed in many disease in the search of biomarkers, particularly cancer proteins. It has great potential to improve both our understanding and clinical management of IBD. Our review summarises the current application of proteomics to IBD and discusses challenges relating to translation into clinical practice.