Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.219
Peer-review started: June 22, 2015
First decision: August 16, 2015
Revised: September 2, 2015
Accepted: October 23, 2015
Article in press: October 28, 2015
Published online: November 15, 2015
Core tip: Ulcerative colitis (UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants (e.g., cyclosporine, tacrolimus), and surgery. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab and adalimumab have been used for moderate to severe UC, and are effective in inducing and maintaining remission in UC. Recent studies have indicated that golimumab, tofacitinib, vedolizumab and etrolizumab achieved good clinical remission and response rates in UC. In this review, we provide updated information on various biological agents in the treatment of UC.