Published online Nov 15, 2015. doi: 10.4291/wjgp.v6.i4.110
Peer-review started: May 29, 2015
First decision: June 18, 2015
Revised: September 26, 2015
Accepted: October 20, 2015
Article in press: October 27, 2015
Published online: November 15, 2015
Core tip: The objective of this article is to relate gastrointestinal microbiota with obesity positively. This idea itself is most innovative. In this article, probable mechanisms involved in relating microbiota with obesity have been discussed. Its key findings are: (1) The gut microbiota play a definite role both in genesis and retardation of obesity; (2) Microbiota-derived lipopolysaccharides and short-chain fatty acids mediate the obesogenic action; (3) Fatty diet not only adds calories but also shifts microbiota compositional pattern in favour of obesity; and (4) The obesogenic actions are mediated through receptor activation, modification of cytokine and endocrine function and gene expression.