Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.51
Peer-review started: February 1, 2015
First decision: March 6, 2015
Revised: March 27, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: August 15, 2015
Core tip: Chronic ethanol administration causes neurodegeneration in the central nervous system. In the enteric nervous system neurodegeneration was not demonstrated, however alcohol-induced quantitative, functional and neurochemical changes of nitrergic myenteric neurons were observed in gut region-dependent way. These suggest that disturbed gastrointestinal transit characteristic to alcoholic patients due to an impairment of a nitric oxide-mediated descending inhibition during peristalsis. The better understanding of the effects of chronic ethanol administration on enteric neurons may reveal new targets for therapy.