Published online Aug 15, 2015. doi: 10.4291/wjgp.v6.i3.43
Peer-review started: January 10, 2015
First decision: March 6, 2015
Revised: March 16, 2015
Accepted: June 1, 2015
Article in press: June 2, 2015
Published online: August 15, 2015
Core tip: Myeloid derived suppressor cells (MDSC) are a heterogeneous population of immune-suppressive cells with important roles during inflammation, infection and cancer. The liver is a primary site for MDSC induction and accumulation, and recent studies linked these cells to the pathogenesis of hepatic inflammation, fibrosis and hepatocellular carcinoma. MDSC can limit tissue injury during acute hepatitis, while they may favor viral persistence in chronic hepatitis. MDSC are also induced during development of liver cancer and suppress anti-tumoral immunity, but their involvement in hepatic fibrosis is less clear. Thus, modulating MDSC functionality might represent a promising novel therapeutic target for liver diseases.