Published online May 15, 2014. doi: 10.4291/wjgp.v5.i2.120
Revised: December 3, 2013
Accepted: April 17, 2014
Published online: May 15, 2014
Core tip: Cytokines play a central role in the induction of appropriate immune responses against hepatitis B, as well as the clinical manifestations of the disease. Dimitropoulou et al showed that serum levels of interleukin 10 and interferon-γ decreased in patients with HBeAg-negative chronic active hepatitis B compared with inactive hepatitis B virus (HBV) carriers (Dimitropoulou et al, 2013) and concluded that this can lead to liver disease. However, we challenge their conclusion because we believe that inappropriate host immune responses are the main causes responsible for the clinical manifestations of the disease, but not the actual replication of the HBV particles.