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World J Gastrointest Pathophysiol. Feb 15, 2014; 5(1): 33-39
Published online Feb 15, 2014. doi: 10.4291/wjgp.v5.i1.33
Published online Feb 15, 2014. doi: 10.4291/wjgp.v5.i1.33
Electrophysiology as a tool to unravel the origin of pancreatic pain
Dina Lelic, Søren Schou Olesen, Carina Graversen, Christina Brock, Asbjørn Mohr Drewes, Mech-Sense, Department of Gastroenterology and Hepatology, Mølleparkvej 4, Aalborg University Hospital, 9000 Aalborg, Denmark
Massimiliano Valeriani, Division of Neurology, Ospedale Pediatrico Bambino Gesù, IRCCS, 00165 Rome, Italy
Massimiliano Valeriani, Asbjørn Mohr Drewes, Department of Health Science and Technology, Center for Sensory-Motor Interactions, Aalborg University, 9000 Aalborg, Denmark
Author contributions: Lelic D, Olesen SS, Graversen C, Brock C, Valeriani M and Drewes AM contributed equally to this work.
Correspondence to: Dina Lelic, MSc, PhD, Mech-Sense, Department of Gastroenterology and Hepatology, Mølleparkvej 4, Aalborg University Hospital, 9000 Aalborg, Denmark. dl@mech-sense.com
Telephone: +45-99-326247 Fax: +45-99-326507
Received: August 27, 2013
Revised: October 14, 2013
Accepted: November 15, 2013
Published online: February 15, 2014
Revised: October 14, 2013
Accepted: November 15, 2013
Published online: February 15, 2014
Core Tip
Core tip: Chronic pancreatitis (CP) is a disease with progressive destruction of the pancreatic gland and intense abdominal pain is one of its main characteristics. The understanding of pain in CP has conventionally focused on the diseased pancreas itself, assuming pain to be due to increased parenchymal or ductal pressure. However, recent research points to possible involvement of abnormal central nervous system pain processing. This review gives an insight into electrophysiology as a tool to unravel brain abnormalities underlying pancreatic pain and provides up to date electrophysiological results in this patient group.