Published online Nov 15, 2013. doi: 10.4291/wjgp.v4.i4.94
Revised: August 28, 2013
Accepted: September 3, 2013
Published online: November 15, 2013
Core tip: The pathogenesis of gastrointestinal diseases is associated with important molecular pathways such as Wnt, Notch, Hippo, transforming growth factor-β/bone morphogenetic protein or Hedgehog in controlling cell-fate determination. Here, we discuss how they contribute to homeostasis of intestinal epithelium.