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World J Gastrointest Pathophysiol. Sep 22, 2026; 17(3): 124717
Published online Sep 22, 2026. doi: 10.4291/wjgp.124717
Published online Sep 22, 2026. doi: 10.4291/wjgp.124717
Intersections of gastrointestinal dysbiosis of the gut microbiome and aging
Sara Shu, Department of Family Medicine, Mayo Clinic, Rochester, MN 55905, United States
Benjamin K P Woo, Chinese American Health Promotion Laboratory, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles Medical Center, Sylmar, CA 91104, United States
Author contributions: Shu S and Woo BKP wrote and edited the manuscript; both authors conceptualized the research topic and submitted the revised manuscript with all the related documents; and all authors thoroughly reviewed and endorsed the final manuscript.
AI contribution statement: No part of the main text of the manuscript, including the Abstract, Introduction, Methods, Results, Discussion, or Conclusion, was AI-generated.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Benjamin K P Woo, Full Professor, Chinese American Health Promotion Laboratory, Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles Medical Center, 14445 Olive View Drive, Sylmar, CA 91104, United States.
Received: June 23, 2026
Revised: July 22, 2026
Accepted: August 14, 2026
Published online: September 22, 2026
Processing time: 77 Days and 22.4 Hours
Revised: July 22, 2026
Accepted: August 14, 2026
Published online: September 22, 2026
Processing time: 77 Days and 22.4 Hours
Core Tip
Core Tip: The gut microbiota changes with age and is influenced by a number of intrinsic and extrinsic factors whose mechanisms continue to be studied and elucidated. We discuss how dysbiosis of the gut microbiome can affect geriatric syndromes, and explore current and future applications of how promotion of a diverse and healthy gut microbiome can influence the health span of our aging population.