Hepatobiliary fascioliasis: A neglected re-emerging threat, its diagnostic and management challenges

doi:10.4291/wjgp.v16.i2.107599

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World Journal of Gastrointestinal Pathophysiology

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2150-5330

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Pathophysiol. Jun 22, 2025; 16(2): 107599
Published online Jun 22, 2025. doi: 10.4291/wjgp.v16.i2.107599

Hepatobiliary fascioliasis: A neglected re-emerging threat, its diagnostic and management challenges

Alaa Ismail, Mohamed Ayman Abdelsalam, Mustafa H Shahin, Yusuf Ahmed, Ibrahim Halil Bahcecioglu, Mehmet Yalniz, Ahmed Tawheed

Alaa Ismail, Mohamed Ayman Abdelsalam, Mustafa H Shahin, Yusuf Ahmed, Faculty of Medicine, Helwan University, Cairo 11795, Al Qāhirah, Egypt

Ibrahim Halil Bahcecioglu, Mehmet Yalniz, Department of Gastroenterology, Firat University, Elazig 23119, Türkiye

Ahmed Tawheed, Department of Gastroenterology, Al Emadi Hospital, Doha 0000, Ad Dawah, Qatar

Author contributions: Tawheed A designed the overall concept and outline of the manuscript; Shain MH and Ahmed Y wrote the manuscript; Abdelsalam MA conducted the database search; Ismail A revised the manuscript; Tawheed A provided important technical details and revised the manuscript; Bahcecioglu IH and Yalniz M revised the manuscript. All authors have contributed to this article and have approved the final version of the manuscript.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ahmed Tawheed, Consultant, Department of Gastroenterology, Al Emadi Hospital, North Road, Doha 0000, Ad Dawah, Qatar. atawheed1990@gmail.com

Received: March 27, 2025
Revised: April 26, 2025
Accepted: May 29, 2025
Published online: June 22, 2025
Processing time: 85 Days and 0.2 Hours

Core Tip

Core Tip: In this review article, we discuss how hepatobiliary fascioliasis, a neglected parasitic disease caused by Fasciola hepatica. Current diagnostic methods, such as stool analysis and serological tests, are unreliable and often linked to false positives. Molecular tests like polymerase chain reaction are not widely available, and new treatments and therapeutic options are needed.