Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Apr 22, 2024; 15(1): 91237
Published online Apr 22, 2024. doi: 10.4291/wjgp.v15.i1.91237
Prognostic significance of tumor budding, desmoplastic reaction, and lymphocytic infiltration in patients with gastric adenocarcinoma
Aysen Yavuz, Kubra Simsek, Anil Alpsoy, Busra Altunay, Elif Ocak Gedik, Betul Unal, Cumhur Ibrahim Bassorgun, Ali Murat Tatli, Gulsum Ozlem Elpek
Aysen Yavuz, Kubra Simsek, Anil Alpsoy, Busra Altunay, Elif Ocak Gedik, Betul Unal, Cumhur Ibrahim Bassorgun, Gulsum Ozlem Elpek, Department of Pathology, Akdeniz University Medical School, Antalya 07070, Türkiye
Ali Murat Tatli, Department of Medical Oncology, Akdeniz University Medical School, Antalya 07070, Türkiye
Author contributions: Yavuz A and Elpek GOE designed and performed the research and wrote the paper; Simsek K, Alpsoy A, Altunay B, Gedik EO, Unal B, and Bassorgun CI are involved in the data curation, investigation, and resources; Tatli AM provided clinical advice; and all authors equally contributed to the analysis of the data.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the Akdeniz University (Approval No. 13.12.2023/915).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous data obtained after each patient agreed to treatment by written permission. One of these forms is presented below.
Conflict-of-interest statement: There is no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupinar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr
Received: December 25, 2023
Peer-review started: December 25, 2023
First decision: February 24, 2024
Revised: March 8, 2024
Accepted: March 22, 2024
Article in press: March 22, 2024
Published online: April 22, 2024
Core Tip

Core Tip: This study investigated the relationships between tumor budding, desmoplastic reaction (DR), and tumor-infiltrating lymphocytes (TILs) in patients with gastric adenocarcinomas (GAC) and assessed their influence on prognosis. Our results demonstrated that TB is a promising prognostic factor in GAC. While it could also be valuable in determining survival in patients with unresectable tumors, further studies are needed to draw a conclusion. Although the DR and TILs were not observed as independent parameters, their close association with TB in patients with GAC suggests their value in predicting tumor behavior merits further research to clarify their roles better.