Case Control Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Pathophysiol. Mar 22, 2023; 14(2): 21-33
Published online Mar 22, 2023. doi: 10.4291/wjgp.v14.i2.21
Polymorphism of genes encoding drug-metabolizing and inflammation-related enzymes for susceptibility to cholangiocarcinoma in Thailand
Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masakazu Tanaka, Nobuyuki Hamajima, Chutiwan Viwatthanasittiphong, Mantana Muangphot, Dhiraphol Chenvidhya, Adisorn Jedpiyawongse, Banchob Sripa, Masanao Miwa, Satoshi Honjo
Gyokukou You, Lu Zeng, Hideaki Tanaka, Emi Ohta, Takahiro Fujii, Kazuhiko Ohshima, Masanao Miwa, Department of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama 526-0829, Shiga, Japan
Masakazu Tanaka, Division of Neuroimmunology, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima 890-8544, Kagoshima, Japan
Nobuyuki Hamajima, Department of Healthcare Administration, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Aichi, Japan
Chutiwan Viwatthanasittiphong, Department of Diagnostic and Interventional Radiology, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand
Mantana Muangphot, Department of Pathology, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand
Dhiraphol Chenvidhya, Department of Surgery, Ubon Cancer Centre, Ubon Ratchathani 34000, Thailand
Adisorn Jedpiyawongse, Research Division, National Cancer Institute, Bangkok 10400, Thailand
Banchob Sripa, Department of Pathology, Khon Kaen University, Khon Kaen 40002, Thailand
Satoshi Honjo, Department of Paediatirics, National Hospital Organization, Fukuoka National Hospital, Fukuoka 811-1394, Fukuoka, Japan
Author contributions: Miwa M secured funds and started the collaborative study in 1998 with the late Srivatanakul P who had been Thai side’s active organizer based on the National Cancer Institute, Bangkok, until her death in 2020; Viwatthanasittiphong C, Muangphot M, Chenvidhya D, Jedpiyawongse A, Sripa B, Honjo S, and Miwa M designed and conducted the epidemiological study; Sripa B measured anti-OV and providing microbiological advice; You G, Zeng L, Tanaka H, Ohta E, Fujii T, Ohshima K, Tanaka M, Hamajima N performed analyses concerning genetic polymorphisms; You G, Zeng L, Miwa M and Honjo S conducted statistical analyses and prepared the manuscript; All authors have read and approved the final manuscript.
Supported by Japan Society for the Promotion of Science, No. 21406011.
Institutional review board statement: This work was conducted after receiving the approval from the ethics committees of the Nagahama Institute of Bio-Science and Technology, Shiga, Japan, and the National Cancer Institute, Bangkok, Thailand.
Informed consent statement: Informed written consent was obtained from the case and control subjects for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no competing interests.
Data sharing statement: Consent for data sharing was not obtained.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Satoshi Honjo, MD, MSc, PhD, Chief Doctor, Senior Researcher, Department of Paediatirics, National Hospital Organization, Fukuoka National Hospital, 1-39-4 Yakatabaru, Minami-ku, Fukuoka 811-1394, Fukuoka, Japan. satoshihonjo@hotmail.com
Received: December 11, 2022
Peer-review started: December 11, 2022
First decision: February 8, 2023
Revised: February 19, 2023
Accepted: March 15, 2023
Article in press: March 15, 2023
Published online: March 22, 2023
Core Tip

Core Tip: Cholangiocarcinoma (CCA) is an intractable cancer, and its prevalence in northeastern Thailand is the highest worldwide. An inflammatory condition produced by infection with the liver fluke Opisthorchis viverrini (OV) has been associated with CCA risk, but the susceptibility of individuals has not been fully examined. Our study revealed that persons with the GSTT1 wild-type and CYP2E1 c1/c2 + c2/c2 genotype had an increased risk for developing CCA (OR = 3.33, 95%CI: 1.23-9.00). Therefore, both gene-gene interactions and OV infection should be considered as risk factors for cholangiocarcinogenesis.