Published online Nov 15, 2016. doi: 10.4291/wjgp.v7.i4.314
Peer-review started: April 8, 2016
First decision: May 19, 2016
Revised: July 30, 2016
Accepted: August 17, 2016
Article in press: August 18, 2016
Published online: November 15, 2016
To investigate the association between hepatitis C virus (HCV) infection and risk of renal cell carcinoma (RCC).
A literature search was performed from inception until February 2016. Studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratio comparing the risk of RCC among HCV-infected participants vs those without HCV infection were included. Participants without HCV infection were used as comparators. Pooled odds ratios and 95%CI were calculated using a random-effect, generic inverse variance method.
Seven observational studies were with 196826 patients were included in the analysis to assess the risk of RCC in patients with HCV. A significantly increased risk of RCC among participants with HCV infection was found with a pooled RR of 1.86 (95%CI: 1.11-3.11). The association between RCC and HCV was marginally insignificant after a sensitivity analysis limited only to studies with adjusted analysis, with a pooled RR of 1.50 (95%CI: 0.93-2.42).
Our study demonstrated a potential association between HCV infection and RCC. Further studies of RCC surveillance in patients with HCV are required.
Core tip: Hepatitis C virus (HCV) is a leading cause of cirrhosis in the United States with a steadily increasing prevalence over the past two decades. Interestingly, HCV infection may also be associated with an increased risk of renal cell carcinoma (RCC) as observed in several epidemiologic studies. To further investigate this possible association, we conducted this systematic review and meta-analysis of observational studies reporting the risk of RCC among HCV-infected patients. We found a significantly increased risk of RCC among participants with HCV infection with the pooled risk ratio of 1.86 (95%CI: 1.11-3.11).