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World J Gastrointest Pathophysiol. Jun 15, 2010; 1(2): 23-29
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.23
Published online Jun 15, 2010. doi: 10.4291/wjgp.v1.i2.23
Aberrant DNA methylation profile in cholangiocarcinoma
Li Huang, Gabriel Frampton, Sharon DeMorrow, Department of Internal Medicine, Texas A&M Health Science Center College of Medicine, Temple, TX 76504, United States
Li Huang, Li-Jian Liang, Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China
Sharon DeMorrow, Digest Disease Research Center, Scott and White Hospital, Temple, TX 76504, United States
Author contributions: Huang L performed literature searches, wrote the review and made editorial corrections; Frampton G performed literature searches and made editorial corrections; Liang LJ contributed conceptually to the work; and DeMorrow S contributed to the concepts and drafting of this review.
Supported by an NIH K01 Grant Award (DK078532) to Dr. DeMorrow
Correspondence to: Sharon DeMorrow, PhD, Department of Internal Medicine, Scott and White Hospital and Texas A&M Health Science Center, Medical Research Building, 702 SW H.K. Dodgen Loop, Temple, TX 76504, United States. demorrow@medicine.tamhsc.edu
Telephone: +1-254-7246240 Fax: +1-254-7248070
Received: February 9, 2010
Revised: May 25, 2010
Accepted: June 1, 2010
Published online: June 15, 2010
Revised: May 25, 2010
Accepted: June 1, 2010
Published online: June 15, 2010
Abstract
Cholangiocarcinoma (CCA) is a notoriously lethal epithelial cancer originating from the biliary system. As radical resection offers a poor success rate and limited effective adjuvant modalities exist in its advanced stage, the disease leads to a fairly poor prognosis. As the incidence of CCA is increasing, although the mortality rate remains stable, and few other definite etiologies have yet to be established, renewing our knowledge of its fundamental carcinogenesis is advisable. The latest advances in molecular carcinogenesis have highlighted the roles of epigenetic perturbations and cancer-related inflammation in CCA. This review focuses on the reciprocal effects between aberrant DNA methylation and inflammatory microenvironment in CCA.
Keywords: Cholangiocarcinoma, Epigenome, DNA methylation, Cancer-related inflammation, Microenvironment