Systematic Reviews
Copyright ©The Author(s) 2016.
World J Radiol. Jun 28, 2016; 8(6): 635-655
Published online Jun 28, 2016. doi: 10.4329/wjr.v8.i6.635
Table 1 Advantages of single photon emission computed tomography/computed tomography for endocrine scintigraphy
Reported benefits of hybrid SPECT/CT imaging99mTc-sestamibi parathyroid scan99mTc-pertechnetate or 123I-thyroid scan131I- or 123I-thyroid cancer scan111In-DTPA octreotide scan131I-NP-59 adrenal cortical scan131I- or 123I-MIBG scan
Precise localization of the radioactivity+ + + ++ ++ + + ++ + + ++ + ++ + + +
Characterization of the radioactivity+ + + ++ ++ + + ++ + + ++ + ++ + + +
Clarification of equivocal radiotracer uptake+ +NA+ + + ++ + + ++ ++ + +
Incremental sensitivity over planar/SPECT+ +NA++ +++
Incremental specificity over planar/SPECT+ + + +NA+ + + ++ + + ++ + ++ + +
Additional information on the non-diagnostic CT+ + +NA+ + ++ + ++ ++ + +
Improved interobserver agreement+ + +NA+ ++ + + +NA+ + +
Improved reader confidence+ + +NA+ + + ++ + + +NA+ + +
Attenuation correction+NA++ +NA+ +
Staging (TNM) of tumorNANA+ + + ++ +NA+
Surveillance and detection of recurrent tumorNANA+ + + ++ + + +NA+ +
Preoperative localization of target for resection+ + + +NA+++ + ++ + +
Confirming of radiotracer avidity as a prerequisite to radionuclide based therapy1NANA+ + + ++ + + +NA+ + +
Exclusion of radiotracer avidity to recommend alternative imaging2NANA+ + ++ + +NA+ + +
Correlation to outcomes and prognosis+ + +NA+ + ++ ++ + + ++ +
Radiation dosimetry (tumor- or organ-specific)NANA+ + ++ + +NANA
Radionuclide imaging times reducedNANA+ ++ + +NANA
Ordering of additional CT/MRI imaging reducedNANA+ + ++ + +++
Change in management+ + + +NA+ + + ++ + + ++ + + ++ + + +
Surgical times reduced+ + + +NANANANANA
Cost-effectiveness+ +NANANANANA