Does computed tomography permeability predict hemorrhagic transformation after ischemic stroke?

Table 1 Characteristics of patients who presented with acute ischemic stroke

Patients (n = 42)	Age	Sex (M/F)	IV tPA	Mechanical	No tPA	Onset to CT (min)	Onset to therapy
No hemorrhage (27; 64.3%)	70.1 ± 12.57	12/15	24 (88.9%)	0	3 (11.1%)	127	168
Hemorrhage (15; 35.7%)	69.9 ± 13.6	7/8	14 (92.9%)	5 (33.3%)	1 (6.7%)	111	143
P value	0.89	0.83	0.7	0.07

CT: Computed tomography; tPA: Tissue plasminogen activator; M: Male; F: Female.

Table 2 The permeability surface area product based on the computed tomography perfusion at the time of hospital presentation

Patients (n = 42)	Permeability surface area product			Relative permeability
	Normal side	Affected side	P value
No hemorrhage (27; 64.3%)	2.32 + 1.38	2.34 + 1.65	0.49	1.04 ± 0.53
Hemorrhage (15; 35.7%)	1.84 + 1.06	3.21 + 1.88	0.002	1.83 ± 0.78
P value	0.18	0.26		0.003

Table 3 Petechial and catastrophic bleeds among patients who experienced intracranial hemorrhage

Patients (n = 15)	Permeability surface area product			Relative permeability
	Normal side	Affected side	P value
Petechial hemorrhage (8; 53.3%)	2.03 + 1.30	3.70 ± 2.28	0.02	1.78 ± 0.66
Hematoma + SAH (7; 46.7%)	1.61 ± 0.75	2.66 ± 1.23	0.06	1.89 ± 0.94
P value	0.92	0.74		0.35

SAH: Subarachnoid haemorrhage.