Copyright ©2014 Baishideng Publishing Group Co.
World J Radiol. Apr 28, 2014; 6(4): 93-105
Published online Apr 28, 2014. doi: 10.4329/wjr.v6.i4.93
Table 1 Summaries of functional magnetic resonance imaging studies investigating autobiographical memory in patients with medial temporal lobe damage
Ref.PathologyPatientsLesion sideRemote memory profileCompensatory Activations
Addis et al[97]Temporal lobe epilepsy11 patientsLeftMild impairment episodic AMmPFC, posterior medial structures
Relative preservation semantic AMmPFC-PHG connectivity
Berry et al[124]Limbic encephalitisSingle-case, Mrs BBilateralImpaired AM (recent events)Left vlPFC, posterior cortices
Maguire et al[72]Developmental amnesiaSingle-case, patient JonBilateralImpaired AM (few preserved events) relatively normal semantic memoryFunctional residual hippocampi mPFC
Maguire et al[77]Hypoxia in late ageSingle-case, patient VCBilateralSevere impairment AMLateral temporal areas (for personal facts)
Maguire et al[110]Semantic dementiaSingle-case, patient AMInitially left later bilateralInitially relatively intact AM followed by gradual deteriorationYear 1: Initially functional right and residual left hippocampi,
Year2: mPFC, vlPFC, precuneus,
Year 3: few occipito-temporal areas
Manning et al[98]Temporal lobe epilepsySingle-case, patient JRLeftPreserved AM, impaired public memoryContro-lesional right MTL, mPFC, posterior cortices
Meulenbroek et al[113]Alzheimer's disease21 patientsBilateralEpisodic-to-semantic shiftmPFC, left vlPFC, posterior cortices
Viard et al[111]Semantic dementiaPatients JPL and EPJPL: bilateralJPL: impaired AMJPL: right hippocampus, vlPFC, occipital areas
EP: bilateral but sparing hippocampiEP: initially relatively preserved AMEP: both hippocampi