Can imaging patterns of neuroendocrine hepatic metastases predict response yttruim-90 radioembolotherapy?

Table 1 Response criteria categories

	Size			Necrosis
	RECIST	WHO	Choi	EASL	Choi
PR	> 30% reduction in unidim-ensional diameter	> 50% reduction in product of greatest bidimensional (perpen- dicular) diameters	> 10% reduction in unidime-nsional diameter	> 50% increase in necrosis	> 15% decrease in tumor density

PR: Partial response; RECIST: Response Evaluation Criteria in Solid Tumors; WHO: World Health Organization; EASL: European Association for the Study of the Liver.

Table 2 Univariate analysis for response

Variable			Size					Necrosis				Size and necrosis
	n	RECIST	P value	WHO	P value	Choi	P value	EASL	P value	Choi	P value	Combined Choi
Total lesions	65
Enhancement			1.00		1.00		0.04		0.18		0.22
Hypo/iso	14	2 (14)		2 (14)		4 (29)		0 (0)		3 (21)		0 (0)
Hyper	51	9 (18)		10 (20)		31 (61)		8 (16)		22 (43)		12 (24)
Necrosis			1.00		0.67		0.32		0.34		0.01
> 50%	10	1 (10)		1 (10)		7 (70)		0 (0)		0 (0)		0 (0)
< 50%	55	10 (18)		11 (20)		28 (51)		8 (15)		25 (45)		12 (22)
Size A (cm)			0.35		1.00		1.00		1.00		1.00
< 2	10	3 (30)		2 (20)		5 (50)		1 (10)		4 (40)		1 (10)
> 2	55	8 (15)		10 (18)		30 (55)		7 (13)		21 (38)		11 (20)
Size B (cm)			0.04		0.002		0.31		0.47		0.07
> 5	25	1 (4)		0 (0)		11 (44)		2 (8)		6 (24)		1 (4)
< 5	40	10 (25)		12 (30)		24 (60)		6 (15)		19 (48)		11 (28)
Tumor burden			1.00		0.74		0.42		1.00		0.79
< 50%	45	8 (18)		9 (20)		26 (58)		6 (13)		18 (40)		8 (18)
> 50%	20	3 (15)		3 (15)		9 (45)		2 (10)		7 (35)		4 (20)

Numbers in parentheses are percentages of lesions meeting criteria. RECIST: Response Evaluation Criteria in Solid Tumors; WHO: World Health Organization; EASL: European Association for the Study of the Liver.