Published online Jun 28, 2015. doi: 10.4329/wjr.v7.i6.131
Peer-review started: January 19, 2015
First decision: February 7, 2015
Revised: March 10, 2015
Accepted: April 10, 2015
Article in press: April 14, 2015
Published online: June 28, 2015
Core tip: Stroke is a major cause of morbidity and mortality all over the world. At-risk patients is so-called vulnerable patients because they posses a higher likelihood of developing symptomatic stroke compared with those low-risk patients. Vulnerable patients usually have carotid artery vulnerable plaques and vulnerable plaques posses a higher likelihood of rupture to lead to acute stroke. The vasa vasorum of carotid artery plaque has been confirmed as same as vulnerable plaques and contrast-enhanced ultrasonography could detect the vasa vasorum of carotid artery plaque.